Saturday, July 7, 2012

Post-Cholecystectomy Syndrome (Symptoms After Gallbladder Surgery)

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An estimated 20 million Americans have gallstones (cholelithiasis), and about 30 percent of these patients will ultimately build symptoms of their gallstone disease. The most base symptoms specifically linked to gallstone disease include upper abdominal pain (often, but not always, following a heavy or greasy meal), nausea, and vomiting. (The upper abdominal pain often radiates colse to towards the right side of the back or shoulder.)

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Patients with complications of untreated cholelithiasis may perceive other symptoms as well, in expanding to an increased risk of severe illness, or even death. These complications of gallstone disease include:

- Severe inflammation or infection of the gallbladder (cholecystitis)

- Blockage of the main bile duct with gallstones (choledocholithiasis), which can cause jaundice or/and bile duct infection (cholangitis), as well as pancreatitis

More than 500,000 patients undergo removal of their gallstones and gallbladders every year in the United States, making cholecystectomy one of the most commonly performed major abdominal surgical operations. In 85 to 90 percent of cholecystectomies, the doing can be performed laparoscopically, using multiple small "band-aid" incisions instead of the original large (and more painful) upper abdominal incision.

For the vast majority of patients with cholelithiasis, cholecystectomy effectively relieves the symptoms of gallstones. In 10 to 15 percent of patients undergoing cholecystectomy, however, persistent or new abdominal or Gi symptoms may arise after gallbladder surgery. Although there are many private causes of persisting post-cholecystectomy abdominal or Gi symptoms, the nearnessy of such symptoms following gallbladder surgery are collectively referred to as "post-cholecystectomy" syndrome (Pcs) by many experts.

I routinely receive inquiries from patients who have previously undergone cholecystectomy, and who description troubling abdominal or Gi symptoms following their surgery. In many cases, these patients have already undergone rather comprehensive evaluations, but without any exact findings. Understandably, such patients are troubled and frustrated, both by their persisting symptoms and the ongoing uncertainty as to the cause (or causes) of these symptoms.

The most base symptoms attributed to Pcs include persisting abdominal pain, nausea, vomiting, bloating, inordinate intestinal gas, and diarrhea. Fever and jaundice, which most commonly arise from complications of gallbladder surgery, are much less common, fortunately. While the correct cause, or causes, of Pcs symptoms can finally be identified in about 90 percent of patients following a proper evaluation, even the most comprehensive work-up can fail to identify a exact ailment as the cause of symptoms in some patients. It is foremost to stress that there is no universal consensus on the topic of Pcs among the experts, although most agree that there are multiple and diverse causes of persisting post-cholecystectomy symptoms. Thus, it can be very difficult to counsel the small minority of patients with persisting symptoms after surgery when a comprehensive work-up fails to identify exact causes for their suffering.

Because Pcs is, in effect, a non-specific clinical diagnosis assigned to patients with persisting symptoms following cholecystectomy, it is critically foremost that an proper work-up be performed in all cases of persisting Pcs, so that an correct diagnosis can be identified, and proper medicine can be initiated. As the known causes of Pcs are numerous, however, physicians caring for such patients need to tailor their evaluations of patients with Pcs based upon clinical findings, as well as prudent laboratory, ultrasound, and radiographic screening exams. This logical clinical advent to the appraisal of Pcs symptoms will identify or eliminate the most base diagnoses linked with Pcs in the majority of such patients, sparing them the need for further unnecessary and invasive testing.

In reviewing the etiologies of Pcs that have been described so far, both patients and physicians can gain a great understanding of how complicated this clinical question is:

- Irritable bowel syndrome (Ibs)

- Bile gastritis (inflammation of the stomach)

- Gastroesophageal reflux (Gerd)

- Hypersensitivity of the nervous theory of the Gi tract

- Abnormal flow of bile into the Gi tract after removal of the gallbladder

- inordinate consumption of fatty and greasy foods

- Painful surgical scars or incisional (scar) hernias

- Adhesions (internal scars) following surgery

- Retained gallstones within the bile ducts or pancreatic duct

- Stricture (narrowing) of the bile ducts

- Bile leaks following surgery

- Injury to bile ducts while surgery

- Infection of the bile ducts (cholangitis), incisions, or abdomen

- Residual gallbladder or cystic duct remnant following surgery

- Fatty changes of the liver or other liver diseases

- persisting pancreatitis or pancreatic insufficiency

- Abnormal function or anatomy of the main bile duct sphincter muscle (the "Sphincter of Oddi")

- Peptic ulcer disease

- Diverticulitis

- Crohn's disease or ulcerative colitis

- Stress

- Psychiatric illnesses

- Tumors of the liver, bile ducts, pancreas, stomach, small intestine, colon, or rectum

In reviewing the comprehensive list of inherent causes of Pcs, it is obvious that some causes of Pcs are directly attributable to cholecystectomy, while many other etiologies are due to unrelated conditions that arise whether prior to surgery or after surgery.

While it is impossible to predict which patients will go on to build Pcs following cholecystectomy, there are some factors that are known to increase the risk of Pcs following surgery. These factors include cholecystectomy performed for causes other than confirmed gallstone disease, cholecystectomy performed on an urgent or emergent basis, patients with a long history of gallstone symptoms prior to undergoing surgery, patients with a prior history of irritable bowel syndrome or other persisting intestinal disorders, and patients with a history of definite psychiatric illnesses.

In my own practice, the initial appraisal of patients with Pcs must, of course, begin with a proper and correct history and corporal exam of the patient. If this initial appraisal is concerning for one of the many known corporal causes of Pcs, then I will regularly ask the sick person undergo several initial screening tests, which typically include blood tests to assess liver and pancreas function, a perfect blood count, and an abdominal ultrasound. Based upon the results of these initial screening tests, some patients may then be advised to undergo further and more sophisticated tests, together with endoscopic ultrasound (Eus), upper or/and lower Gi endoscopy (including, in some cases, Ercp, or endoscopic retrograde cholangiopancreatography), bile duct manometry, or Ct or Mri scans, for example. (The decision to order any of these more invasive and more precious tests must, of course, be dictated by each private patient's clinical scenario.)

Fortunately, as I indicated at the beginning of this column, a thoughtful and logical advent to each private patient's presentation will lead to a exact diagnosis in more than 90 percent of all cases of Pcs. Therefore, if you (or man you know) are experiencing symptoms consistent with Pcs, then referral to a doctor with expertise in evaluating and treating the varied causes of Pcs is critical (such physicians can include family physicians, internists, Gi specialists, and surgeons). Once a exact cause for your Pcs symptoms is identified, then an proper medicine plan can be initiated.

Disclaimer: As always, my advice to readers is to seek the advice of your doctor before making any critical changes in medications, diet, or level of corporal activity.

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